USP4

Across TCGA patient cohorts, USP4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,083 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible USP4-associated proteins across cancer lineages are RGS10, GPX1, and LMNB2. Each is linked with USP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP4-to-partner and partner-to-USP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP4 versus RGS10 in CCRCC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USP4→partner) and Y-score (partner→USP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RGS10 →	+0.446	+0.331	<.001	<.001	3	4
PDAC	GPX1 →	+0.354	+0.302	<.001	<.001	3	4
PDAC	LMNB2 →	+0.294	+0.275	<.001	<.001	3	4
BRCA	PTPN23 →	+0.280	+0.415	<.001	<.001	3	4
GBM	TASOR →	+0.236	+0.339	<.001	<.001	3	4
PDAC	SEC62_T158 →	-0.871	-0.250	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,083 associations by consensus.

USP4 vs RGS10 — CCRCC

Explore this scatter interactively →