USP4

Across TCGA patient cohorts, USP4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,954 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USP4-associated genes across cancer lineages are TEX264, KLHL18, and APEH. Each is linked with USP4 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP4-to-partner and partner-to-USP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP4 versus TEX264 in OV, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP4→partner) and Y-score (partner→USP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TEX264 →	+0.429	+0.228	.003	.002	3	5
COAD	KLHL18 →	+0.439	+0.214	<.001	.002	3	5
LUAD	APEH →	+0.486	+0.212	<.001	<.001	3	5
BRCA	SPCS1 →	+0.462	+0.215	<.001	<.001	3	5
BRCA	CYB561D2 →	+0.608	+0.211	<.001	.001	3	5
CCRCC	PLEKHA1 →	-0.583	-0.117	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,954 associations by consensus.

USP4 vs TEX264 — OV

Explore this scatter interactively →