USP4

Across TCGA patient cohorts, USP4 mutation is significantly associated with the RNA expression of many other genes, with 1,792 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP4-associated genes across cancer lineages are RN7SKP221, SNRPEP9, and SNORA3C. Each is linked with USP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP4-to-partner and partner-to-USP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by USP4-low versus USP4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP4→partner) and Y-score (partner→USP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	3
HNSC	SNRPEP9 →	+0.170	+4.224	<.001	.003	3	3
LUSC	SNORA3C →	+0.553	+4.416	.002	.002	3	3
BRCA	MIR7159 →	+0.476	+5.317	<.001	.006	3	2
UCEC	CCM2L →	-0.402	-3.427	.003	.005	3	2
CESC	NFYAP1 →	+0.165	+4.595	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,792 associations by consensus.

RN7SKP221 by USP4 expression — BRCA

Explore this box plot interactively →