USP4

Across TCGA cell cohorts, USP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,937 significant associations in total. CNS shows the largest number of these associations.

The most reproducible USP4-associated GO terms across cancer lineages are Positive regulation of pinocytosis, Microtubule cytoskeleton organization involved in mitosis, and Regulation of Wnt protein secretion. Each is linked with USP4 in more than 14 cancer types. Because this analysis shows association rather than direction, both USP4-to-partner and partner-to-USP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of pinocytosis grouped by USP4-low versus USP4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP4→partner) and Y-score (partner→USP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of pinocytosis →	+0.138	+0.657	<.001	<.001	3	15
LARGE_INTESTINE	Microtubule cytoskeleton organization involved in mitosis →	+0.068	+0.643	.001	.001	3	13
BREAST	Regulation of Wnt protein secretion →	+0.139	+0.593	<.001	.002	3	13
BLOOD_Leukemia	Microtubule polymerization →	+0.101	+0.626	<.001	<.001	3	12
BREAST	Positive regulation of Wnt protein secretion →	+0.128	+0.622	<.001	.001	3	12
CNS	Protein depolymerization →	+0.110	+0.646	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,937 associations by consensus.

Positive regulation of pinocytosis by USP4 expression — SOFT_TISSUE

Explore this box plot interactively →