USP4

Across TCGA cell cohorts, USP4 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP4-associated genes across cancer lineages are GHRHR, LRIT1, and TACR3. Each is linked with USP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP4-to-partner and partner-to-USP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by USP4-low versus USP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP4→partner) and Y-score (partner→USP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.370	+3.705	<.001	.007	3	1
BLOOD_Leukemia	LRIT1 →	+0.037	+4.269	<.001	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.034	+4.060	<.001	.003	3	1
BLOOD_Leukemia	OR1N1 →	+0.071	+4.234	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	VWC2L →	+0.012	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GHRHR by USP4 expression — BLOOD_Leukemia

Explore this box plot interactively →