USP38

Across TCGA pan-cancer cohorts, USP38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP38 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher USP38 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP38 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where USP38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.832	0.167	.006	30	view →
PDAC	OS	Quartile	III,IV	0.228	0.672	.010	17	view →
CCRCC	OS	Median	All	1.000	0.860	.030	12	view →
HNSC	DFS	Median	IV	0.938	0.623	.012	10	view →
LSCC	OS	Median	III,IV	0.996	0.625	.010	6	view →
LUAD	DFS	Quartile	III,IV	1.000	0.305	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP38–UCEC (DFS)

Open the UCEC breakdown →