USP38

Across TCGA patient cohorts, USP38 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP38-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and MEK1. Each is linked with USP38 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP38-to-partner and partner-to-USP38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by USP38-low versus USP38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP38→partner) and Y-score (partner→USP38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.410	+2.906	<.001	.001	3	3
UCEC	JNK_pT183_Y185 →	-0.193	-2.662	<.001	<.001	3	2
UCEC	MEK1 →	+0.490	+2.321	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.305	+1.512	.003	.017	3	2
UCEC	PDCD4 →	-0.492	-1.716	.001	.003	3	2
UCEC	Shc_pY317 →	-0.168	-1.925	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by USP38 expression — UCEC

Explore this box plot interactively →