USP38

Across TCGA cell cohorts, USP38 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP38-associated genes across cancer lineages are GAGE12G, SPACA1, and AVP. Each is linked with USP38 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP38-to-partner and partner-to-USP38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12G grouped by USP38-low versus USP38-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP38→partner) and Y-score (partner→USP38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GAGE12G →	+0.088	+5.754	<.001	.002	3	1
STOMACH	SPACA1 →	+0.017	+4.285	<.001	.007	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1
LARGE_INTESTINE	C2CD5 →	+0.578	+3.212	.008	.006	3	1
LARGE_INTESTINE	TNP1 →	+0.079	+3.192	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

GAGE12G by USP38 expression — CNS

Explore this box plot interactively →