USP37

Across TCGA patient cohorts, USP37 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP37-associated genes across cancer lineages are C-Raf, FoxM1, and ACVRL1. Each is linked with USP37 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP37-to-partner and partner-to-USP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by USP37-low versus USP37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP37→partner) and Y-score (partner→USP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.146	+2.087	.001	.005	3	3
BLCA	FoxM1 →	+0.265	+3.000	.030	.036	3	2
UCEC	ACVRL1 →	-0.102	-1.342	.020	.034	3	2
UCEC	p62 Lck ligand →	+0.339	+2.000	.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.153	-1.700	.013	.040	3	2
UCEC	ATM →	-0.328	-1.459	.025	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by USP37 expression — UCEC

Explore this box plot interactively →