USP37

Across TCGA cell cohorts, USP37 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,881 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP37-associated GO terms across cancer lineages are DNA-templated DNA replication maintenance of fidelity, Centrosome duplication, and Microtubule nucleation. Each is linked with USP37 in more than 19 cancer types. Because this analysis shows association rather than direction, both USP37-to-partner and partner-to-USP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication maintenance of fidelity grouped by USP37-low versus USP37-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP37→partner) and Y-score (partner→USP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.126	+1.062	<.001	<.001	3	20
OESOPHAGUS	Centrosome duplication →	+0.115	+0.799	<.001	.001	3	20
BONE	Microtubule nucleation →	+0.129	+0.711	<.001	<.001	3	19
BONE	Mitotic sister chromatid cohesion →	+0.141	+0.961	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Centrosome cycle →	+0.089	+1.075	<.001	.005	3	19
BONE	Centriole replication →	+0.103	+0.648	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,881 associations by consensus.

DNA-templated DNA replication maintenance of fidelity by USP37 expression — BLOOD_Myeloma

Explore this box plot interactively →