USP37

Across TCGA cell cohorts, USP37 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP37-associated genes across cancer lineages are PTH, MYF5, and MMP26. Each is linked with USP37 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP37-to-partner and partner-to-USP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by USP37-low versus USP37-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP37→partner) and Y-score (partner→USP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH →	+0.046	+3.514	<.001	.001	3	2
CNS	MYF5 →	+0.756	+5.321	<.001	.005	3	1
SKIN	MMP26 →	+0.020	+5.022	<.001	.002	3	1
BLOOD_Leukemia	C1QL2 →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ACTRT2 →	+0.064	+4.922	.001	.009	3	1
BLOOD_Leukemia	MC2R →	+0.006	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PTH by USP37 expression — LARGE_INTESTINE

Explore this box plot interactively →