USP34

Across TCGA pan-cancer cohorts, USP34 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP34 data layer compared with 27 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher USP34 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP34 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where USP34 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.287	0.951	.006	11	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.698	.004	8	view →
CCRCC	OS	Median	All	0.740	1.000	.021	7	view →
GBM	DFS	Tertile	All	0.577	0.379	.029	4	view →
UCEC	DFS	Tertile	III,IV	1.000	0.483	.042	4	view →
HNSC	OS	Median	All	1.000	0.960	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP34–PDAC (DFS)

Open the PDAC breakdown →