USP34

Across TCGA patient cohorts, USP34 mutation is significantly associated with the RNA expression of many other genes, with 8,453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP34-associated genes across cancer lineages are DNAJA1, RNU1-62P, and KPNB1. Each is linked with USP34 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP34-to-partner and partner-to-USP34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJA1 grouped by USP34-low versus USP34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP34→partner) and Y-score (partner→USP34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJA1 →	+0.489	+2.050	<.001	<.001	3	5
CESC	RNU1-62P →	+0.148	+3.316	<.001	.005	3	4
UCEC	KPNB1 →	+0.447	+1.479	<.001	<.001	3	4
STAD	NSD2 →	+0.585	+3.104	<.001	<.001	3	4
STAD	CNOT6 →	+0.442	+2.415	.001	.003	3	4
STAD	RPF1 →	+0.361	+2.448	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,453 associations by consensus.

DNAJA1 by USP34 expression — UCEC

Explore this box plot interactively →