USP34

Across TCGA cell cohorts, USP34 mutation is significantly associated with the RNA expression of many other genes, with 2,594 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP34-associated genes across cancer lineages are NUP88, NGLY1, and NDC80. Each is linked with USP34 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP34-to-partner and partner-to-USP34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP88 grouped by USP34-low versus USP34-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP34→partner) and Y-score (partner→USP34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP88 →	+0.504	+2.584	<.001	.002	3	4
BLOOD_Leukemia	NGLY1 →	+0.476	+2.489	.007	.007	3	4
LARGE_INTESTINE	NDC80 →	+0.571	+2.672	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CDC123 →	+0.596	+3.459	.002	.002	3	3
LARGE_INTESTINE	PPP4R3A →	+0.464	+2.377	<.001	<.001	3	3
BLOOD_Leukemia	MID1 →	+0.731	+3.214	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,594 associations by consensus.

NUP88 by USP34 expression — LARGE_INTESTINE

Explore this box plot interactively →