USP33

Across TCGA pan-cancer cohorts, USP33 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated USP33 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher USP33 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USP33 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, KIRP, and COAD are the cancer types where USP33 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.166	0.707	<.001	30	view →
KIRP	OS	Median	All	0.188	0.903	<.001	21	view →
COAD	OS	Median	III,IV	0.082	0.792	<.001	18	view →
UCEC	DFS	Median	II,III,IV	0.941	0.712	.022	12	view →
LUSC	OS	Median	All	0.446	0.822	.019	6	view →
BLCA	OS	Median	III,IV	0.217	0.586	.017	3	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

USP33–ESCA (OS)

Open the ESCA breakdown →