USP33

Across TCGA pan-cancer cohorts, USP33 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP33 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP33 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USP33 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where USP33 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.640	1.000	.008	9	view →
UCEC	DFS	Tertile	III,IV	1.000	0.594	.049	4	view →
HNSC	DFS	Tertile	III,IV	0.894	1.000	.018	4	view →
LSCC	DFS	Quartile	III,IV	0.632	1.000	.026	3	view →
PDAC	OS	Quartile	All	0.272	0.458	.021	2	view →
GBM	OS	Median	All	0.938	0.769	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP33–CCRCC (OS)

Open the CCRCC breakdown →