USP33

Across TCGA patient cohorts, USP33 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP33-associated genes across cancer lineages are mTOR_pS2448, Rictor_pT1135, and ASNS. Each is linked with USP33 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP33-to-partner and partner-to-USP33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by USP33-low versus USP33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP33→partner) and Y-score (partner→USP33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.164	-2.302	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.081	-1.353	.012	.015	3	2
UCEC	ASNS →	+0.313	+1.584	.005	.032	3	2
UCEC	ATM →	-0.578	-1.836	<.001	.001	3	2
UCEC	Dvl3 →	+0.119	+1.502	.040	.027	3	2
SKCM	Bcl-xL →	-0.204	-2.987	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

mTOR_pS2448 by USP33 expression — UCEC

Explore this box plot interactively →