USP32

Across TCGA pan-cancer cohorts, USP32 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated USP32 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher USP32 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP32 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

CESC, COAD, and THCA are the cancer types where USP32 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.163	0.716	<.001	12	view →
COAD	DFS	Median	All	0.239	0.693	.009	8	view →
THCA	DFS	Median	All	0.089	0.841	<.001	6	view →
HNSC	DFS	Median	IV	0.116	0.670	.002	6	view →
ESCA	OS	Median	All	0.080	0.681	<.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
SCLC	OS	Median	All	0.219	0.650	.031	3	view →
UCEC	DFS	Median	II,III,IV	0.840	0.434	.035	2	view →
SKCM	OS	Median	All	0.966	0.867	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

USP32–CESC (DFS)

Open the CESC breakdown →