USP32

Across TCGA patient cohorts, USP32 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP32-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and FASN. Each is linked with USP32 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP32-to-partner and partner-to-USP32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP32-low versus USP32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP32→partner) and Y-score (partner→USP32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.637	+1.945	<.001	.002	3	4
UCEC	eIF4E →	+0.162	+1.415	.013	.010	3	3
UCEC	FASN →	+0.255	+2.000	.037	.009	3	3
UCEC	p62 Lck ligand →	+0.418	+2.999	<.001	<.001	3	3
UCEC	PCNA →	+0.238	+3.087	<.001	<.001	3	3
UCEC	C-Raf →	+0.149	+1.514	<.001	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by USP32 expression — UCEC

Explore this box plot interactively →