USP31

Across TCGA pan-cancer cohorts, USP31 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of USP31’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where USP31 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types USP31 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD, PDAC, and LSCC are the cancer types where USP31 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP31 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.317	<.001	5	view →
PDAC	All	All	−0.507	.019	4	view →
LSCC	Female	All	+0.403	.015	1	view →
CCRCC	Male	All	−0.319	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

USP31–LUAD

Open the LUAD breakdown →