USP3

Across TCGA pan-cancer cohorts, USP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where USP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	37	view →
PDAC	OS	Quartile	All	0.407	0.636	.021	16	view →
CCRCC	DFS	Quartile	III,IV	0.050	0.978	.038	6	view →
LUAD	DFS	Median	II,III,IV	0.757	0.935	.004	6	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.454	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP3–HNSC (OS)

Open the HNSC breakdown →