USP3-AS1

Across TCGA pan-cancer cohorts, USP3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated USP3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher USP3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USP3-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

UVM, LUSC, and LGG are the cancer types where USP3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.294	1.000	<.001	100	view →
LUSC	OS	Quartile	All	0.805	0.650	<.001	55	view →
LGG	DFS	Tertile	All	0.649	0.807	<.001	31	view →
BRCA	DFS	Tertile	III,IV	0.884	0.707	.003	24	view →
UCS	DFS	Tertile	IV	0.981	0.484	.024	18	view →
OV	DFS	Tertile	IV	0.300	0.556	.017	18	view →
READ	OS	Tertile	II,III,IV	0.888	0.278	.003	17	view →
KIRP	DFS	Tertile	All	0.456	0.769	.001	14	view →
CHOL	DFS	Tertile	III,IV	0.232	0.779	.024	12	view →
MESO	OS	Quartile	All	0.842	0.384	.017	12	view →
STAD	OS	Quartile	All	0.813	0.454	.036	9	view →
SKCM	DFS	Tertile	All	0.247	0.147	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

USP3-AS1–UVM (OS)

Open the UVM breakdown →