USP27X

Across TCGA pan-cancer cohorts, USP27X mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated USP27X data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher USP27X mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP27X expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

GBM and UCEC are the cancer types where USP27X mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.448	0.219	.007	9	view →
UCEC	DFS	Median	All	0.946	0.750	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

USP27X–GBM (DFS)

Open the GBM breakdown →