USP27X

Across TCGA patient cohorts, USP27X protein abundance is significantly associated with the RNA expression of many other genes, with 1,735 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP27X-associated genes across cancer lineages are SLC1A6, CRHR2, and ZNF365. Each is linked with USP27X in more than 1 cancer types. Because this analysis shows association rather than direction, both USP27X-to-partner and partner-to-USP27X results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP27X versus SLC1A6 in GBM, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP27X→partner) and Y-score (partner→USP27X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC1A6 →	+0.469	+0.556	<.001	.002	3	2
GBM	CRHR2 →	+0.732	+0.648	<.001	<.001	3	2
GBM	ZNF365 →	+0.803	+0.453	.001	.007	3	2
LSCC	EPHB1 →	+2.138	+0.444	<.001	.001	3	2
GBM	NPTXR →	+1.988	+0.793	<.001	<.001	3	2
UCEC	LINC02254 →	+1.195	+0.438	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,735 associations by consensus.

USP27X vs SLC1A6 — GBM

Explore this scatter interactively →