USP27X

Across TCGA patient cohorts, USP27X mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP27X-associated genes across cancer lineages are PCNA, TIGAR, and ASNS. Each is linked with USP27X in more than 1 cancer types. Because this analysis shows association rather than direction, both USP27X-to-partner and partner-to-USP27X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by USP27X-low versus USP27X-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP27X→partner) and Y-score (partner→USP27X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.303	+1.882	.003	.031	3	2
COAD	TIGAR →	+0.344	+1.882	.038	.031	3	2
COAD	ASNS →	+0.557	+1.882	<.001	.031	3	2
COAD	c-Met_pY1235 →	+0.158	+3.321	<.001	.009	3	2
UCEC	STAT3_pY705 →	-0.243	-1.584	.001	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.556	+1.341	.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

PCNA by USP27X expression — COAD

Explore this box plot interactively →