USP24

Across TCGA pan-cancer cohorts, USP24 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated USP24 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher USP24 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP24 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, UCEC, and LUSC are the cancer types where USP24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
UCEC	DFS	Median	All	0.955	0.610	.002	32	view →
LUSC	DFS	Median	III,IV	0.079	0.658	<.001	12	view →
BLCA	OS	Median	III,IV	0.215	0.547	.015	11	view →
LGG	OS	Median	All	0.242	0.802	<.001	7	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
LIHC	DFS	Median	All	0.098	0.530	.002	6	view →
SKCM	DFS	Median	II,III,IV	0.949	0.677	.015	5	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

USP24–ACC (DFS)

Open the ACC breakdown →