USP22

Across TCGA patient cohorts, USP22 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,493 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP22-associated proteins across cancer lineages are SAMSN1, PSME2, and APBB2. Each is linked with USP22 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP22-to-partner and partner-to-USP22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP22 versus SAMSN1 in CCRCC, with a Pearson correlation of -0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USP22→partner) and Y-score (partner→USP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SAMSN1 →	-0.601	-0.363	<.001	<.001	3	6
LUAD	PSME2 →	-0.359	-0.431	<.001	.001	3	5
BRCA	APBB2 →	+0.347	+0.500	.002	.006	3	5
GBM	VSIR →	-0.415	-0.314	<.001	<.001	3	5
LSCC	SASH3 →	-0.439	-0.545	<.001	.005	3	5
LSCC	MLKL →	-0.570	-0.550	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,493 associations by consensus.

USP22 vs SAMSN1 — CCRCC

Explore this scatter interactively →