USP22

Across TCGA patient cohorts, USP22 protein abundance is significantly associated with the RNA expression of many other genes, with 11,688 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USP22-associated genes across cancer lineages are BRIP1, B9D1, and TMEM97. Each is linked with USP22 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP22-to-partner and partner-to-USP22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP22 versus BRIP1 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP22→partner) and Y-score (partner→USP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRIP1 →	+0.956	+0.309	<.001	<.001	3	5
HNSC	B9D1 →	+0.646	+0.404	<.001	<.001	3	5
HNSC	TMEM97 →	+0.908	+0.422	<.001	<.001	3	5
GBM	SOX4 →	+1.050	+0.349	<.001	<.001	3	5
LSCC	MCM8 →	+0.917	+0.521	<.001	<.001	3	5
UCEC	MMS22L →	+0.715	+0.349	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,688 associations by consensus.

USP22 vs BRIP1 — UCEC

Explore this scatter interactively →