USP22

Across TCGA cell cohorts, USP22 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP22-associated genes across cancer lineages are KRT85, DACT2, and SMR3B. Each is linked with USP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP22-to-partner and partner-to-USP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT85 grouped by USP22-low versus USP22-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP22→partner) and Y-score (partner→USP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT85 →	+0.078	+3.781	<.001	<.001	3	2
BLOOD_Lymphoma	DACT2 →	+0.024	+3.502	.002	.003	3	1
BLOOD_Lymphoma	SMR3B →	+0.171	+3.021	<.001	.006	3	1
BLOOD_Lymphoma	KRT9 →	+0.029	+3.021	<.001	.006	3	1
BLOOD_Lymphoma	GSX2 →	+0.872	+3.688	.004	.005	3	1
BLOOD_Lymphoma	OR2L8 →	+0.018	+3.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

KRT85 by USP22 expression — BLOOD_Lymphoma

Explore this box plot interactively →