USP20

Across TCGA cell cohorts, USP20 mutation is significantly associated with the RNA expression of many other genes, with 434 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP20-associated genes across cancer lineages are OR4N4, TEX46, and MSH4. Each is linked with USP20 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP20-to-partner and partner-to-USP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by USP20-low versus USP20-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP20→partner) and Y-score (partner→USP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4N4 →	+0.105	+4.191	<.001	.007	3	2
LARGE_INTESTINE	TEX46 →	+0.122	+2.649	<.001	<.001	3	2
LARGE_INTESTINE	MSH4 →	+0.232	+2.357	<.001	<.001	3	2
PANCREAS	NEUROG1 →	+0.032	+4.614	<.001	.004	3	1
PANCREAS	NCR1 →	+0.043	+4.786	<.001	.001	3	1
PANCREAS	SMIM9 →	+0.027	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 434 associations by consensus.

OR4N4 by USP20 expression — BLOOD_Lymphoma

Explore this box plot interactively →