USP2

Across TCGA patient cohorts, USP2 mutation is significantly associated with the RNA expression of many other genes, with 2,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP2-associated genes across cancer lineages are MIR6889, RNU6-414P, and RNU6-436P. Each is linked with USP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP2-to-partner and partner-to-USP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6889 grouped by USP2-low versus USP2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP2→partner) and Y-score (partner→USP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6889 →	+0.854	+4.378	<.001	.006	3	2
LIHC	RNU6-414P →	+0.298	+5.008	<.001	.004	3	2
LIHC	RNU6-436P →	+0.252	+4.758	<.001	.006	3	2
LUSC	SNORA10B →	+0.334	+3.565	.001	.007	3	2
LUSC	NUS1P3 →	+0.102	+3.484	<.001	.005	3	2
LUSC	PSPC1P2 →	+0.100	+4.191	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,350 associations by consensus.

MIR6889 by USP2 expression — LIHC

Explore this box plot interactively →