USP2

Across TCGA patient cohorts, USP2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP2-associated genes across cancer lineages are 4E-BP1, GAPDH, and p27_pT198. Each is linked with USP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP2-to-partner and partner-to-USP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by USP2-low versus USP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP2→partner) and Y-score (partner→USP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.334	+3.459	<.001	.005	3	2
UCEC	GAPDH →	+0.447	+1.700	.020	.042	3	2
UCEC	p27_pT198 →	+0.087	+2.115	.023	.017	3	2
UCEC	TFRC →	+0.447	+2.321	.019	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.588	+2.459	.005	.018	3	2
UCEC	C-Raf →	+0.144	+1.906	.005	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

4E-BP1 by USP2 expression — UCEC

Explore this box plot interactively →