USP2

Across TCGA cell cohorts, USP2 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP2-associated genes across cancer lineages are ASB17, C1orf87, and CST9. Each is linked with USP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP2-to-partner and partner-to-USP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by USP2-low versus USP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP2→partner) and Y-score (partner→USP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
BLOOD_Lymphoma	CST9 →	+0.060	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SPANXN4 →	+0.117	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.019	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CXorf51B →	+2.803	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASB17 by USP2 expression — OVARY

Explore this box plot interactively →