USP2-AS1

Across TCGA pan-cancer cohorts, USP2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated USP2-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher USP2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USP2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

BLCA, LGG, and KICH are the cancer types where USP2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	All	0.638	0.773	.010	46	view →
LGG	OS	Median	All	0.343	0.540	<.001	45	view →
KICH	OS	Median	All	0.661	1.000	.001	31	view →
HNSC	DFS	Quartile	All	0.256	0.554	<.001	29	view →
COAD	DFS	Tertile	II,III,IV	0.700	0.823	.015	17	view →
PRAD	DFS	Tertile	All	0.669	0.854	.003	16	view →
UCS	DFS	Tertile	II,III,IV	0.698	0.307	.008	14	view →
LUAD	OS	Median	II,III,IV	0.634	0.427	.009	12	view →
KIRP	DFS	Median	II,III,IV	0.276	0.686	.011	12	view →
THCA	DFS	Quartile	II,III,IV	0.658	0.920	.008	10	view →
LAML	DFS	Median	All	0.272	0.502	.017	10	view →
BRCA	OS	Tertile	IV	0.775	0.370	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

USP2-AS1–BLCA (OS)

Open the BLCA breakdown →