Across TCGA pan-cancer cohorts, USP18 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated USP18 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher USP18 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP18 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, MESO, and UCEC are the cancer types where USP18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.100	0.757	<.001	18	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
UCEC	DFS	Median	All	1.000	0.629	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: USP18 tumor-vs-normal RNA expression · all USP18 data types