Across TCGA pan-cancer cohorts, USP18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP18 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher USP18 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP18 expression acts as an unfavorable survival marker, although some lineages such as OV and LSCC show a favorable association.

OV, GBM, and LSCC are the cancer types where USP18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	All	1.000	0.407	.045	8	view →
GBM	DFS	Tertile	All	0.344	0.853	.024	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.221	.024	6	view →
LUAD	DFS	Median	All	0.459	0.861	.006	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: USP18 tumor-vs-normal RNA expression · all USP18 data types