Across TCGA patient cohorts, USP18 protein abundance is significantly associated with the RNA expression of many other genes, with 2,714 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible USP18-associated genes across cancer lineages are IFIT1, IFI6, and OASL. Each is linked with USP18 in more than 6 cancer types. Because this analysis shows association rather than direction, both USP18-to-partner and partner-to-USP18 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP18→partner) and Y-score (partner→USP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IFIT1 →	+3.318	+1.173	.004	.001	3	7
HNSC	IFI6 →	+1.904	+1.038	<.001	<.001	3	6
GBM	OASL →	+2.326	+1.039	.002	.002	3	6
GBM	IFI44L →	+2.505	+0.673	.004	.008	3	6
GBM	HERC6 →	+2.636	+0.894	.005	.009	3	6
GBM	HERC5 →	+1.936	+0.918	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

Exploration

USP18 survival (RNA) · tumor vs normal (RNA) · all USP18 data types