Across TCGA patient cohorts, USP18 mutation is significantly associated with the RNA expression of many other genes, with 739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP18-associated genes across cancer lineages are MTATP6P20, RN7SL685P, and RN7SL173P. Each is linked with USP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP18-to-partner and partner-to-USP18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP18→partner) and Y-score (partner→USP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTATP6P20 →	+0.115	+5.098	<.001	<.001	3	1
SKCM	RN7SL685P →	+0.081	+4.282	<.001	.009	3	1
SKCM	RN7SL173P →	+0.411	+4.508	<.001	.001	3	1
UCEC	YTHDF3-AS1 →	+0.698	+2.724	<.001	.003	3	1
UCEC	DOC2B →	-1.262	-2.906	<.001	.002	3	1
UCEC	TAF9 →	+0.589	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 739 associations by consensus.

Exploration

USP18 survival (RNA) · tumor vs normal (RNA) · all USP18 data types