Across TCGA patient cohorts, USP18 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP18-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK_pT183_Y185, and MSH2. Each is linked with USP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP18-to-partner and partner-to-USP18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP18→partner) and Y-score (partner→USP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.593	+2.700	.009	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.218	-3.169	.004	.018	3	1
UCEC	MSH2 →	-0.225	-2.973	.030	.035	3	1
UCEC	p27_pT198 →	+0.116	+2.000	.016	.032	3	1
UCEC	S6_pS240_S244 →	+0.583	+3.169	.001	.019	3	1
UCEC	STAT3_pY705 →	-0.556	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

USP18 survival (RNA) · tumor vs normal (RNA) · all USP18 data types