Across TCGA cell cohorts, USP18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP18-associated GO terms across cancer lineages are MDA-5 signaling pathway, Antiviral innate immune response, and Interferon-mediated signaling pathway. Each is linked with USP18 in more than 14 cancer types. Because this analysis shows association rather than direction, both USP18-to-partner and partner-to-USP18 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP18→partner) and Y-score (partner→USP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.240	+1.369	<.001	<.001	3	15
LARGE_INTESTINE	Antiviral innate immune response →	+0.109	+1.958	<.001	<.001	3	14
CNS	Interferon-mediated signaling pathway →	+0.144	+1.744	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.180	+1.536	<.001	<.001	3	13
KIDNEY	Defense response to virus →	+0.101	+2.250	.003	<.001	3	13
CNS	Type I interferon-mediated signaling pathway →	+0.139	+1.543	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

Exploration

USP18 survival (RNA) · tumor vs normal (RNA) · all USP18 data types