USP17L1

Across TCGA pan-cancer cohorts, USP17L1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated USP17L1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher USP17L1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USP17L1 expression acts as an unfavorable survival marker, although some lineages such as TGCT and UCS show a favorable association.

COAD, THCA, and BLCA are the cancer types where USP17L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.142	0.871	<.001	81	view →
THCA	DFS	Tertile	III,IV	0.761	0.900	.019	33	view →
BLCA	OS	Tertile	All	0.456	0.631	.012	27	view →
UCEC	DFS	Tertile	All	0.258	0.661	.016	24	view →
TGCT	DFS	Tertile	All	0.950	0.735	.003	18	view →
OV	DFS	Tertile	IV	0.290	0.497	.044	18	view →
UCS	DFS	Tertile	II,III,IV	0.736	0.214	.018	18	view →
LIHC	DFS	Tertile	III,IV	0.113	0.341	.011	18	view →
PRAD	DFS	Tertile	All	0.972	0.724	.001	18	view →
HNSC	OS	Tertile	All	0.706	0.795	.004	17	view →
ESCA	DFS	Median	All	1.000	0.533	.012	15	view →
ACC	DFS	Tertile	III,IV	0.137	0.489	.029	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

USP17L1–COAD (OS)

Open the COAD breakdown →