USP15

Across TCGA pan-cancer cohorts, USP15 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP15 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher USP15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP15 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where USP15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.873	1.000	.013	48	view →
PDAC	OS	Median	III,IV	0.622	0.873	.015	13	view →
CCRCC	DFS	Quartile	All	1.000	0.742	.001	11	view →
HNSC	OS	Quartile	III,IV	0.985	0.749	.033	9	view →
LUAD	OS	Tertile	II,III,IV	0.495	0.800	.024	5	view →
LSCC	DFS	Quartile	All	0.797	0.306	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP15–COAD (DFS)

Open the COAD breakdown →