USP15

Across TCGA patient cohorts, USP15 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP15-associated genes across cancer lineages are ATM, ACC1, and INPP4B. Each is linked with USP15 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP15-to-partner and partner-to-USP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP15-low versus USP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP15→partner) and Y-score (partner→USP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.675	-2.058	<.001	<.001	3	4
UCEC	ACC1 →	+0.255	+2.013	.028	.004	3	2
UCEC	INPP4B →	-0.262	-2.502	.011	.001	3	2
UCEC	p62 Lck ligand →	+0.365	+1.775	<.001	.007	3	2
UCEC	Rad50 →	-0.235	-1.523	.002	.008	3	2
UCEC	TIGAR →	+0.103	+1.096	.034	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by USP15 expression — UCEC

Explore this box plot interactively →