USP15

Across TCGA cell cohorts, USP15 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,169 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible USP15-associated GO terms across cancer lineages are Regulation of defense response to fungus, Regulation of antifungal innate immune response, and Monoubiquitinated protein deubiquitination. Each is linked with USP15 in more than 11 cancer types. Because this analysis shows association rather than direction, both USP15-to-partner and partner-to-USP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of defense response to fungus grouped by USP15-low versus USP15-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP15→partner) and Y-score (partner→USP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of defense response to fungus →	+0.184	+0.706	<.001	<.001	3	12
BONE	Regulation of antifungal innate immune response →	+0.184	+0.706	<.001	<.001	3	12
CNS	Monoubiquitinated protein deubiquitination →	+0.113	+0.555	<.001	<.001	3	11
LARGE_INTESTINE	snRNA transcription →	+0.061	+0.425	<.001	.007	3	10
BLOOD_Myeloma	Transcription elongation-coupled chromatin remodeling →	+0.120	+0.798	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Protein localization to condensed chromosome →	+0.159	+0.689	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

Regulation of defense response to fungus by USP15 expression — BONE

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