USP15

Across TCGA cell cohorts, USP15 mutation is significantly associated with the RNA expression of many other genes, with 717 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP15-associated genes across cancer lineages are UGT2B10, BPIFB3, and LYZL2. Each is linked with USP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP15-to-partner and partner-to-USP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT2B10 grouped by USP15-low versus USP15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP15→partner) and Y-score (partner→USP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UGT2B10 →	+0.006	+4.977	<.001	.007	3	1
SKIN	BPIFB3 →	+0.030	+6.022	<.001	.001	3	1
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	ACSM2A →	+0.028	+4.523	<.001	.003	3	1
LUNG_SCLC	KRTAP19-2 →	+0.127	+4.643	<.001	.004	3	1
STOMACH	GPR31 →	+0.101	+3.209	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 717 associations by consensus.

UGT2B10 by USP15 expression — SKIN

Explore this box plot interactively →