USP13

Across TCGA pan-cancer cohorts, USP13 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP13 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP13 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP13 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where USP13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.669	0.883	.005	33	view →
PDAC	OS	Tertile	II,III,IV	0.484	0.234	.003	30	view →
LUAD	OS	Quartile	II,III,IV	0.879	0.399	.003	29	view →
LSCC	DFS	Median	III,IV	0.572	1.000	.002	11	view →
UCEC	DFS	Median	II,III,IV	0.923	0.490	.005	6	view →
CCRCC	OS	Median	II,III,IV	0.588	1.000	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP13–HNSC (DFS)

Open the HNSC breakdown →