USP13

Across TCGA pan-cancer cohorts, USP13 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of USP13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where USP13 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types USP13 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and PDAC are the cancer types where USP13 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP13 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.340	<.001	8	view →
COAD	Male	III,IV	−0.510	<.001	6	view →
PDAC	Female	II,III,IV	−0.393	<.001	6	view →
CCRCC	Male	All	−0.246	<.001	6	view →
LUAD	Male	III,IV	−0.388	<.001	3	view →
LSCC	Female	All	−0.291	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

USP13–HNSC

Open the HNSC breakdown →