USP13

Across TCGA patient cohorts, USP13 mutation is significantly associated with the RNA expression of many other genes, with 2,462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP13-associated genes across cancer lineages are MIR3199-1, ATP6V1E1P2, and COX6CP3. Each is linked with USP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP13-to-partner and partner-to-USP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3199-1 grouped by USP13-low versus USP13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP13→partner) and Y-score (partner→USP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3199-1 →	+0.482	+4.118	<.001	.004	3	3
UCEC	ATP6V1E1P2 →	+0.102	+1.644	.001	.002	3	3
LUAD	COX6CP3 →	+0.221	+3.405	<.001	.001	3	3
UCEC	MCM5 →	+0.408	+1.443	.006	.003	3	2
UCEC	TXN2 →	+0.236	+2.032	.007	.004	3	2
UCEC	CDKN3 →	+0.564	+2.169	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,462 associations by consensus.

MIR3199-1 by USP13 expression — SKCM

Explore this box plot interactively →