USP13

Across TCGA patient cohorts, USP13 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP13-associated genes across cancer lineages are ATM, JNK2, and TSC1. Each is linked with USP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP13-to-partner and partner-to-USP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP13-low versus USP13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP13→partner) and Y-score (partner→USP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-3.893	<.001	<.001	3	3
UCEC	JNK2 →	+0.150	+1.290	.016	.034	3	2
UCEC	TSC1 →	-0.119	-1.661	.027	.040	3	2
UCEC	Cyclin-B1 →	+0.455	+3.321	.010	.009	3	2
LUSC	SCD →	+0.169	+2.816	.002	.036	3	1
UCEC	EGFR_pY1068 →	-0.159	-1.353	.044	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by USP13 expression — UCEC

Explore this box plot interactively →