USP13

Across TCGA cell cohorts, USP13 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,012 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP13-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of mitotic metaphase/anaphase transition, and Positive regulation of cell cycle. Each is linked with USP13 in more than 16 cancer types. Because this analysis shows association rather than direction, both USP13-to-partner and partner-to-USP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by USP13-low versus USP13-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP13→partner) and Y-score (partner→USP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of metaphase/anaphase transition of cell cycle →	+0.109	+1.126	<.001	.001	3	17
KIDNEY	Regulation of mitotic metaphase/anaphase transition →	+0.112	+0.980	<.001	<.001	3	17
BREAST	Positive regulation of cell cycle →	+0.071	+1.149	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of cell cycle process →	+0.084	+0.752	<.001	<.001	3	17
PANCREAS	Regulation of DNA-templated DNA replication →	+0.117	+1.246	<.001	<.001	3	17
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.105	+0.930	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,012 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by USP13 expression — PANCREAS

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